PVT1通过微小RNA促进癌症进展。
PVT1 Promotes Cancer Progression via MicroRNAs.
作者信息
Wang Wenxi, Zhou Ruoyu, Wu Yuwei, Liu Yicong, Su Wenjia, Xiong Wei, Zeng Zhaoyang
机构信息
NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.
The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China.
出版信息
Front Oncol. 2019 Jul 15;9:609. doi: 10.3389/fonc.2019.00609. eCollection 2019.
Non-coding RNA (ncRNA) plays a regulatory role in a variety of cellular activities. And long non-coding RNA (lncRNA) is one of the important kinds of ncRNA. Previous studies have shown that various lncRNAs are involved in the progression of cancer. LncRNA plasmacytoma variant translocation 1 (PVT1) is a newly discovered oncogenic factor that has been confirmed to be overexpressed in many cancer cells. Moreover, the role of PVT1 in cancer development is closely linked to microRNAs (miRNAs). PVT1 can act as a "sponge" for miRNAs to inhibit their activities, thereby affecting proliferation, invasion, and angiogenesis of cancer. In addition, PVT1 itself can be spliced and processed into several miRNAs such as miR-1204 and miR-1207, which can also regulate the development of cancer. This review summarizes various pathways through which PVT1 regulates the progression of cancer via miRNAs. We also propose additional regulatory mechanisms of PVT1 and their potential clinical applications.
非编码RNA（ncRNA）在多种细胞活动中发挥调节作用。长链非编码RNA（lncRNA）是ncRNA的重要类型之一。先前的研究表明，多种lncRNA参与癌症进展。lncRNA浆细胞瘤变异易位1（PVT1）是一种新发现的致癌因子，已证实其在许多癌细胞中过表达。此外，PVT1在癌症发展中的作用与微小RNA（miRNA）密切相关。PVT1可作为miRNA的“海绵”来抑制其活性，从而影响癌症的增殖、侵袭和血管生成。此外，PVT1自身可剪接加工成若干miRNA，如miR - 1204和miR - 1207，它们也可调节癌症发展。本综述总结了PVT1通过miRNA调节癌症进展的各种途径。我们还提出了PVT1的其他调节机制及其潜在的临床应用。
Zotero 插件