欧洲南部糖尿病人群糖化血红蛋白的季节性变化。

Seasonal variability of glycated hemoglobin in a diabetic population from southern Europe.

机构信息

Internal Medicine Department, Hospital Regional Universitario Carlos Haya, Malaga, Spain; Ciber Fisiopatología de la Obesidad y Nutrición (CB06/003) Instituto de Salud Carlos III, Madrid, Spain.

出版信息

J Diabetes Complications. 2013 Nov-Dec;27(6):618-20. doi: 10.1016/j.jdiacomp.2013.04.013. Epub 2013 Jul 31.

DOI:10.1016/j.jdiacomp.2013.04.013

PMID:23916500

Abstract

AIMS

To analyze the seasonal variations in A1c levels among a southern European diabetic population.

METHODS

We examined all monthly-grouped A1c determinations from diabetic patients during the period 2006-2011, in a region of southern Spain.

RESULTS

There were 61,329 records available. The mean A1c value was 56mmol/mol (7.2%±1.7%) (95% CI, 55-56mmol/mol (7.2%-7.3%), with a range of 0.2%. The highest value was in February and the lowest in July (56mmol/mol (7.3%) and 54mmol/mol (7.1%), respectively) (P<0.01). However, spectral analysis and correlation coefficients did not reach significance, and the series presented no seasonal pattern.

CONCLUSIONS

In our area, although the A1C levels have some monthly fluctuation they show no significant seasonal pattern. Thus, the seasonal fluctuation of HbA1c is not a limitation for decision making in clinical practice.

摘要

目的

分析南欧糖尿病人群 A1c 水平的季节性变化。

方法

我们检查了西班牙南部一个地区 2006-2011 年间所有按月份分组的糖尿病人的 A1c 测定值。

结果

共获得 61329 份记录。平均 A1c 值为 56mmol/mol（7.2%±1.7%）（95%CI，55-56mmol/mol（7.2%-7.3%），范围为 0.2%。最高值在 2 月，最低值在 7 月（分别为 56mmol/mol（7.3%）和 54mmol/mol（7.1%））（P<0.01）。然而，频谱分析和相关系数没有达到显著性，该系列没有表现出季节性模式。