Department of Pharmaceutical Sciences, Dibrugarh University, Assam, 786004, India.
Int J Biol Macromol. 2013 Oct;61:333-9. doi: 10.1016/j.ijbiomac.2013.07.017. Epub 2013 Aug 2.
The purpose of this research was to develop and evaluate Albizia procera gum as compression-coating polymer for colonic delivery of budesonide. Tablets were prepared by direct compression method using spray-dried lactose and microcrystalline cellulose as filler binders. The compatibility between the drug and the polymer was studied through TGA and FTIR spectroscopy. In vitro drug release were studied in dissolution media with or without 2% rat cecal contents while in vivo X-ray study was conducted on rabbits. The results indicate that procera gum and the drug were compatible with each other and tablet coated with procera gum was suitable for colonic delivery of drugs.
本研究旨在开发和评价金合欢胶作为包衣聚合物用于直肠给药用布地奈德的传递。采用喷雾干燥乳糖和微晶纤维素作为填充粘结剂的直接压片法制备片剂。通过热重分析和傅里叶变换红外光谱研究了药物与聚合物之间的相容性。在含有或不含有 2%大鼠盲肠内容物的溶解介质中进行了体外药物释放研究，同时在兔体内进行了 X 射线研究。结果表明，金合欢胶与药物相互兼容，并且用金合欢胶包衣的片剂适合于药物的结肠传递。
