Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, PR China.
Brain Res. 2013 Sep 19;1531:1-8. doi: 10.1016/j.brainres.2013.07.041. Epub 2013 Jul 31.
A substantial amount of evidence has shown that treadmill running enhances neurogenesis, improves cognitive function, and protects the brain against neurodegenerative disorders. However, treadmill running is a type of forced exercise that could increase the level of corticosterone, which subsequently down-regulates neurogenesis and impairs cognitive function. The purpose of this study was to investigate if regular treadmill running provides a balance between the positive and negative effects of treadmill running. The mice were divided into four groups: controls (CON), regular runners (RR), irregular duration runners (IDR) and irregular time-of-day runners (ITR). The RR mice ran daily on the treadmill at the same time-of-day, speed and duration. The IDR mice ran at the same time-of-day and speed, but for a different duration. The ITR mice ran at the same speed and duration, but at different time-of-day. The results showed that regular treadmill running could increase neurogenesis and improve spatial learning and memory performance, as well as decrease the level of corticosterone. The present finding emphasizes the importance of regular physical exercise on cognition.
大量证据表明，跑步机跑步可以促进神经发生、改善认知功能并保护大脑免受神经退行性疾病的侵害。然而，跑步机跑步是一种强迫性运动，可能会增加皮质酮水平，从而下调神经发生并损害认知功能。本研究旨在探讨定期跑步机跑步是否能在跑步机跑步的积极和消极影响之间取得平衡。将小鼠分为四组：对照组（CON）、常规跑步组（RR）、不定时跑步组（IDR）和不定时跑步时间组（ITR）。RR 组小鼠每天在跑步机上以相同的时间、速度和时间跑。IDR 组小鼠在相同的时间和速度下跑步，但时间不同。ITR 组小鼠以相同的速度和时间跑步，但时间不同。结果表明，定期跑步机跑步可以增加神经发生，改善空间学习和记忆表现，并降低皮质酮水平。本研究结果强调了定期体育锻炼对认知的重要性。
