Gene Regulation Laboratory, Genome Institute of Singapore, Singapore 138672, Singapore; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 117456, Singapore.
Semin Cell Dev Biol. 2013 Dec;24(10-12):670-8. doi: 10.1016/j.semcdb.2013.07.002. Epub 2013 Aug 2.
The identity of a cell is determined by the concerted interplay of multiple molecular modulators such as transcription factors, chromatin modifiers and signalling mediators. Among these, the transcriptional circuitry holds great influence on the specification and maintenance of a cellular state, and its perturbation can trigger a transition to another cell state. This is particularly striking in the field of pluripotency, where tempering the expression levels of one or few transcription factors is sufficient to induce the loss or acquisition of the pluripotent state. Recently, nuclear receptors, a class of transcription factors, have emerged as major players in the molecular network governing pluripotency. In this review, we discuss the importance of nuclear receptors in embryonic stem cell self-renewal, differentiation and cellular reprogramming, highlighting recent discoveries as well as providing an outlook in stem cell and nuclear receptor research.
细胞的身份由多种分子调节剂的协同相互作用决定，如转录因子、染色质修饰剂和信号转导介质。在这些因素中，转录电路对细胞状态的特化和维持有很大的影响，其干扰可以触发向另一种细胞状态的转变。这在多能性领域尤为明显，只需调节一个或少数几个转录因子的表达水平，就足以诱导多能状态的丧失或获得。最近，核受体作为转录因子的一类，已成为调控多能性的分子网络中的主要参与者。在这篇综述中，我们讨论了核受体在胚胎干细胞自我更新、分化和细胞重编程中的重要性，强调了最近的发现，并对干细胞和核受体研究提供了展望。
