Division of Pediatric Neurosurgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Falk Brain Tumor Center, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Development Biology Department, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Departments of Biomedical and Mechanical Engineering, Northwestern University, Evanston, IL, USA.
Nanomedicine. 2014 Feb;10(2):381-91. doi: 10.1016/j.nano.2013.07.013. Epub 2013 Aug 3.
This study examined a novel drug delivery system for treatment of malignant brain gliomas: DOX complexed with nanodiamonds (ND-Dox), and administered via convection-enhanced delivery (CED). Drug retention and toxicity were examined in glioma cell lines, and distribution, retention and toxicity were examined in normal rat parenchyma. Efficacy was assessed in a bioluminescence rodent tumor model. NDs markedly enhanced DOX uptake and retention in glioma cells. ND-Dox delivered via CED extended DOX retention and localized DOX toxicity in normal rodent parenchyma, and was significantly more efficient at killing tumor cells than uncomplexed DOX. Outcomes from this work suggest that CED of ND-Dox is a promising approach for brain tumor treatment.
In this paper, nanodiamonds were utilized to enhance delivery of DOX in a preclinical glioma model using a convection-enhanced delivery method, demonstrating remarkably enhanced efficacy.
与纳米金刚石（ND-Dox）复合的 DOX，并通过对流增强递送（CED）给药。在神经胶质瘤细胞系中检查了药物保留和毒性，在正常大鼠实质中检查了分布、保留和毒性。在生物发光啮齿动物肿瘤模型中评估了疗效。NDs 显著增强了 DOX 在神经胶质瘤细胞中的摄取和保留。通过 CED 递送的 ND-Dox 延长了 DOX 的保留时间，并使正常啮齿动物实质中的 DOX 毒性局部化，并且比未复合的 DOX 更有效地杀死肿瘤细胞。这项工作的结果表明，CED 的 ND-Dox 是一种有前途的脑肿瘤治疗方法。
在本文中，利用纳米金刚石增强了使用对流增强递送方法的临床前神经胶质瘤模型中 DOX 的递送，显示出显著增强的疗效。
