甲基苯丙胺对单侧黑质损伤大鼠脑局部葡萄糖利用的影响。
Effects of methamphetamine on regional cerebral glucose utilization in rats with unilateral lesion of substantia nigra.
作者信息
Gomita Y, Ichimaru Y, Furuno K, Araki Y
机构信息
Department of Hospital Pharmacy, Okayama University Medical School, Japan.
出版信息
Jpn J Pharmacol. 1990 Jul;53(3):414-8. doi: 10.1254/jjp.53.414.
In rats with electrocoagulation of the unilateral substantia nigra (SN), methamphetamine at doses of 2.5 and 5 mg/kg, i.p., induced ipsilateral turning towards the lesioned side and caused an imbalance of the regional cerebral glucose utilization (CGU) in the caudate-putamen (CP), frontal cortex (FC) and ventromedial thalamic nucleus (VMT); i.e., showing a higher contralateral CGU as compared with the SN lesioned side. These results induced in unilateral SN-lesioned rats may be accompanied by an imbalance of neural activity in CP, FC and VMT of these rats.
在单侧黑质（SN）电凝毁损的大鼠中，腹腔注射2.5和5mg/kg剂量的甲基苯丙胺可诱导大鼠向损伤侧同侧旋转，并导致尾状核-壳核（CP）、额叶皮质（FC）和丘脑腹内侧核（VMT）区域脑葡萄糖利用（CGU）失衡；即与SN损伤侧相比，对侧CGU更高。单侧SN损伤大鼠出现的这些结果可能伴随着这些大鼠CP、FC和VMT神经活动的失衡。
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