Mazullo Filho João Batista Raposo, Bona Silvia, Rosa Darlan Pase da, Silva Fabiano Gomes da, Forgiarini Junior Luiz Alberto, Dias Alexandre Simões, Marroni Norma Possa
Rev Bras Ter Intensiva. 2012 Mar;24(1):23-9.
Mechanical ventilation is a mainstay of therapy in intensive care units; however, its deleterious effects need to be assessed. Therefore, we aimed to assess oxidative stress in patients admitted to an intensive care unit undergoing invasive mechanical ventilation.
This cross-sectional study included 12 invasive mechanical ventilation patients. Blood samples (3 mL) were collected on the first and last days on invasive mechanical ventilation. Thiobarbituric acid-reacting substances (TBARS) were assessed in plasma, and superoxide dismutase (SOD) and catalase (CAT) were assessed in erythrocytes.
The mean age was 64.8 ± 17.6 years, the tidal volume (VT) 382 ± 44.5 mL, and the APACHE II score 15 ± 7. When initial and final TBARS were compared, a significant difference was identified (3.54 ± 0.74 vs. 4.96 ± 1.47, p = 0.04). Antioxidant enzymes showed no significant differences. Correlations between PaO2/FiO2 and TBARS (r = 0.4), SOD and PaO2/FiO2 (r = 0.51) and APACHE II and SOD (r = 0.56) were identified. Six patients died.
Patients undergoing invasive mechanical ventilation can develop redox state changes, showing increased TBARS and reduced antioxidant enzymes.
机械通气是重症监护病房治疗的主要手段；然而，其有害影响需要评估。因此，我们旨在评估入住重症监护病房并接受有创机械通气患者的氧化应激情况。
这项横断面研究纳入了12例接受有创机械通气的患者。在有创机械通气的第一天和最后一天采集血样（3毫升）。检测血浆中的硫代巴比妥酸反应物质（TBARS），并检测红细胞中的超氧化物歧化酶（SOD）和过氧化氢酶（CAT）。
平均年龄为64.8±17.6岁，潮气量（VT）为382±44.5毫升，急性生理与慢性健康状况评分系统（APACHE II）评分为15±7。比较初始和最终的TBARS时，发现有显著差异（3.54±0.74对4.96±1.47，p = 0.04）。抗氧化酶无显著差异。确定了动脉血氧分压/吸入氧分数值（PaO2/FiO2）与TBARS之间的相关性（r = 0.4）、SOD与PaO2/FiO2之间的相关性（r = 0.51）以及APACHE II与SOD之间的相关性（r = 0.56）。6例患者死亡。
接受有创机械通气的患者可出现氧化还原状态变化，表现为TBARS升高和抗氧化酶降低。
