重症监护病房中的药物-营养相互作用：文献综述与当前建议
Drug-nutrient interactions in the intensive care unit: literature review and current recommendations.
作者信息
Heldt Tatiane, Loss Sergio Henrique
机构信息
Integrated Multidisciplinary Residency Program in Health with emphasis in Adult Critical Care, Hospital de Clínicas de Porto Alegre - Porto Alegre RS, Brazil.
出版信息
Rev Bras Ter Intensiva. 2013 Apr-Jun;25(2):162-7. doi: 10.5935/0103-507X.20130028.
OBJECTIVE
To describe the interactions between drugs and nutrients and their frequency in the intensive care unit and to assess the professional team's awareness regarding this subject.
METHODS
The keywords "drug interactions" and "nutrition therapy" were searched in the PubMed (specifically MeSH) electronic database. The studies were systematically reviewed for descriptions of the types of interactions between drugs and nutrients, including their frequency and consequences.
RESULTS
Sixty-seven articles were found. Among these, 20 articles were appropriate for the methodology adopted and accomplished the objectives of the study. Of these 20 articles, 14 articles described interactions between drugs and enteral nutrition, three described interactions between drugs and parenteral nutrition, and three described the importance and care required to avoid such interactions.
CONCLUSIONS
The literature about drug and nutrient interactions is limited and suggests the inability of health care teams to recognize the potential for these interactions. Possibly, the elaboration of a protocol to evaluate drug-nutrient interactions will increase the safety and efficacy of therapeutics.
目的
描述重症监护病房中药物与营养物质之间的相互作用及其发生频率，并评估专业团队对该主题的认知情况。
方法
在PubMed（特别是医学主题词表）电子数据库中搜索关键词“药物相互作用”和“营养治疗”。对这些研究进行系统综述，以了解药物与营养物质之间相互作用的类型描述，包括其频率和后果。
结果
共找到67篇文章。其中，20篇文章适合所采用的方法并实现了研究目标。在这20篇文章中，14篇描述了药物与肠内营养之间的相互作用，3篇描述了药物与肠外营养之间的相互作用，3篇描述了避免此类相互作用所需的重要性和注意事项。
结论
关于药物与营养物质相互作用的文献有限，这表明医疗团队无法识别这些相互作用的可能性。制定评估药物 - 营养相互作用的方案可能会提高治疗的安全性和有效性。
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