Meerson F Z, Khalfen E Sh, Liamina N P
Kardiologiia. 1990 May;30(5):56-9.
Responses of healthy subjects and patients with a cardiac type neurocirculatory dystonia (NCD) to exercise and stress were evaluated. Stress was ascertained to cause a higher enhancement of catecholamine excretion than exercise. In patients with NCD, resting adrenaline (A) excretion was increased by 50%, whereas the noradrenaline (NA) one remained unchanged. The A/NA ratio showed a more than 1.5-fold increase. A stress-induced rise in NA excretion was 4 times higher in NCD patients than in healthy subjects. In the patients, resting dopamine (D) excretion was lower and the D/A + NA ratio was decreased both at rest and during exercise. In NCD the higher adrenergic response to stress was followed by the occurrence of arrhythmias in more than a half of the patients. The healthy subjects and the patients with NCD developed no arrhythmias during exercise. It has been suggested that changes in adrenergic control and associated arrhythmias are caused by dysfunction of the stress-limiting systems in NCD.
评估了健康受试者和患有心脏型神经循环性肌张力障碍（NCD）的患者对运动和压力的反应。已确定压力比运动导致更高的儿茶酚胺排泄增强。在患有NCD的患者中，静息肾上腺素（A）排泄增加了50%，而去甲肾上腺素（NA）排泄保持不变。A/NA比值显示增加了1.5倍以上。NCD患者中压力诱导的NA排泄增加比健康受试者高4倍。在这些患者中，静息多巴胺（D）排泄较低，并且在静息和运动期间D/A + NA比值均降低。在NCD中，对压力的较高肾上腺素能反应之后，超过一半的患者出现心律失常。健康受试者和患有NCD的患者在运动期间均未出现心律失常。有人提出，肾上腺素能控制的变化及相关心律失常是由NCD中压力限制系统功能障碍引起的。
