宿主信号转导与蛋白激酶在军团菌感染中的作用。
Host signal transduction and protein kinases implicated in Legionella infection.
机构信息
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, 02111, USA.
出版信息
Curr Top Microbiol Immunol. 2013;376:249-69. doi: 10.1007/82_2013_342.
Abstract
Modulation of the phosphorylation status of proteins by both kinases and phosphatases plays an important role in cellular signal transduction. Challenge of host cells by Legionella pneumophila manipulates the phosphorylation state of multiple host factors. These changes play roles in bacterial uptake, vacuole modification, cellular survival, and the immune response. In addition to modification by host cell kinases in response to the bacterium, L. pneumophila translocates bacterial kinases into the host cell that may contribute to further signaling modifications. Proper regulation of host cell signaling by L. pneumophila is necessary for its ability to replicate intracellulary, while avoiding host defenses.
摘要
蛋白的磷酸化状态受激酶和磷酸酶的共同调节，在细胞信号转导中发挥着重要作用。嗜肺军团菌对宿主细胞的挑战会改变多种宿主因子的磷酸化状态。这些变化在细菌摄取、空泡修饰、细胞存活和免疫反应中发挥作用。除了宿主细胞激酶在细菌刺激下的修饰作用外，嗜肺军团菌还将细菌激酶转运到宿主细胞中，这可能有助于进一步的信号修饰。嗜肺军团菌对宿主细胞信号的适当调节对于其在细胞内复制的能力以及逃避宿主防御是必要的。
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