Han Linxiao, Liu Yanyan, Cao Weiwei, Yuan Xiuying, Li Cuifeng
Department of Gynecology, The Shilong People's Hospital of Dongguan, Dongguan, 523326, China,
Tumour Biol. 2013 Oct;34(5):2545-50. doi: 10.1007/s13277-013-0798-8. Epub 2013 Aug 7.
Many studies proposed that cytochrome P450 1A1 (CYP1A1) MspI polymorphism may be associated with endometrial cancer risk, but the findings from previous studies reported conflicting results. A meta-analysis of all relevant studies was performed to get a comprehensive assessment of the association between CYP1A1 MspI polymorphism and endometrial cancer risk. Eligible studies were searched in PubMed and China National Knowledge Infrastructure databases. The pooled odds ratios (ORs) with the corresponding 95 % confidence intervals (95 % CIs) were calculated to evaluate the association. Twelve studies with a total of 2,111 cases and 2,894 controls were finally included into the meta-analysis. Overall, meta-analysis of a total of 12 studies showed that there was no obvious association between CYP1A1 MspI polymorphism and endometrial cancer risk (ORC vs. T = 0.97, 95 % CI 0.77-1.22, P OR = 0.808; ORCC vs. TT = 1.00, 95 % CI 0.57-1.76, P OR = 0.994; ORCC vs. TT/TC = 0.88, 95 % CI 0.65-1.20, P OR = 0.425; ORCC/TC vs. TT = 0.98, 95 % CI 0.74-1.29, P OR = 0.861). Subgroup analyses by ethnicity further showed that there was no obvious association between CYP1A1 MspI polymorphism and endometrial cancer risk in both Caucasians and Asians. There was no obvious risk of publication bias. Therefore, the meta-analysis suggests that CYP1A1 MspI polymorphism is not associated with endometrial cancer risk.
许多研究表明，细胞色素P450 1A1（CYP1A1）MspI基因多态性可能与子宫内膜癌风险相关，但以往研究结果相互矛盾。为全面评估CYP1A1 MspI基因多态性与子宫内膜癌风险之间的关联，我们对所有相关研究进行了荟萃分析。在PubMed和中国知网数据库中检索符合条件的研究。计算合并比值比（OR）及相应的95%置信区间（95%CI）以评估两者之间的关联。最终，共有12项研究纳入荟萃分析，涉及2111例病例和2894例对照。总体而言，对这12项研究的荟萃分析显示，CYP1A1 MspI基因多态性与子宫内膜癌风险之间无明显关联（OR C vs. T = 0.97，95%CI 0.77 - 1.22，P OR = 0.808；OR CC vs. TT = 1.00，95%CI 0.57 - 1.76，P OR = 0.994；OR CC vs. TT/TC = 0.88，95%CI 0.65 - 1.20，P OR = 0.425；OR CC/TC vs. TT = 0.98，95%CI 0.74 - 1.29，P OR = 0.861）。按种族进行的亚组分析进一步表明，在白种人和亚洲人中，CYP1A1 MspI基因多态性与子宫内膜癌风险之间均无明显关联。不存在明显的发表偏倚风险。因此，荟萃分析表明CYP1A1 MspI基因多态性与子宫内膜癌风险无关。
