Kah James Chen Yong
National University Singapore, Singapore, Singapore.
Methods Mol Biol. 2013;1025:119-26. doi: 10.1007/978-1-62703-462-3_9.
Colloidal stability of nanoparticles in biological media is crucial to preserve their utility as aggregation often leads to undesirable biological response. A quantitative measurement of nanoparticles aggregation in solution would provide a valuable assessment of colloidal stability of bio-nano interfaces after surface functionalization. Here, we develop a quantitative technique based on optical absorption to assay the colloidal stability of plasmonic nanoparticles functionalized with different amphiphilic surface ligands in biologically relevant media.
纳米颗粒在生物介质中的胶体稳定性对于保持其效用至关重要，因为聚集往往会导致不良的生物反应。对溶液中纳米颗粒聚集进行定量测量，将为表面功能化后生物纳米界面的胶体稳定性提供有价值的评估。在此，我们开发了一种基于光吸收的定量技术，以测定在生物相关介质中用不同两亲性表面配体功能化的等离子体纳米颗粒的胶体稳定性。
