Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Am J Perinatol. 2014 May;31(5):413-8. doi: 10.1055/s-0033-1352486. Epub 2013 Aug 5.
To investigate the effect of prostaglandin E2 (PGE2) on electrical uterine activity using a novel uterine muscle electromyography device in patients undergoing induction of labor.
Electrical uterine myography (EUM) was prospectively measured using a noninvasive nine channels recorder in 31 women undergoing induction of labor with vaginal PGE2 tablets. Women were monitored before and up to 12 hours after vaginal PGE2 application. EUM index was defined as mean electrical activity of the uterine muscle over a period of 10 minutes measured in units of microjoule (µJ, µWs).
The EUM index was not increased significantly during the first 2 hours following PGE2 application (overall increase of 5.3 ± 60.1%, p = 0.7). Peak EUM activity was observed during 2 to 8 hours following PGE2 application, which represented a statistically significant increase compared with the EUM index before PGE2 application (3.3 ± 0.5 µJ vs. 2.5 ± 0.95 µJ, p = 0.01), and with the EUM index 0 to 2 hours following PGE2 application (3.3 ± 0.5 µJ vs. 2.3 ± 0.9 µJ, p = 0.004).
The data suggests that in women undergoing labor induction with PGE2, uterine activity peaks 2 to 8 hours following PGE2 application. This information may provide more insight into the mechanism of PGE2 action.
使用新型子宫肌电图仪研究前列腺素 E2（PGE2）对分娩诱导患者子宫电活动的影响。
对 31 名接受阴道 PGE2 片引产的患者前瞻性地使用非侵入性九通道记录仪进行子宫电描记术（EUM）测量。在阴道 PGE2 应用前和应用后 12 小时内对患者进行监测。EUM 指数定义为测量 10 分钟内子宫肌电活动的平均值，单位为微焦耳（µJ，µWs）。
在阴道 PGE2 应用后 2 小时内，EUM 指数没有显著增加（总体增加 5.3±60.1%，p=0.7）。在阴道 PGE2 应用后 2 至 8 小时达到 EUM 活动峰值，与 PGE2 应用前的 EUM 指数（3.3±0.5µJ 比 2.5±0.95µJ，p=0.01）和 PGE2 应用后 0 至 2 小时的 EUM 指数（3.3±0.5µJ 比 2.3±0.9µJ，p=0.004）相比，EUM 活动有统计学显著增加。
数据表明，在接受 PGE2 引产的女性中，子宫活动在 PGE2 应用后 2 至 8 小时达到峰值。这些信息可能为 PGE2 作用机制提供更多的深入了解。
