血清 CA-125 在韩国女性腹水患者中的临床意义。

Clinical significance of serum CA-125 in Korean females with ascites.

机构信息

Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Korea.

出版信息

Yonsei Med J. 2013 Sep;54(5):1241-7. doi: 10.3349/ymj.2013.54.5.1241.

DOI:10.3349/ymj.2013.54.5.1241

PMID:23918576

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3743200/

Abstract

PURPOSE

Mycobacterium tuberculosis is endemic in Korea. Because tuberculous peritonitis is characterized by ascites, abdominal pain, abdominal mass and elevation of serum CA-125, it can be confused with ovarian malignancies. The aim of this study was to evaluate the significance of serum CA-125 level in the differential diagnosis of tuberculous peritonitis and ovarian malignancy in a Mycobacterium tuberculosis-endemic area.

MATERIALS AND METHODS

The medical records of patients diagnosed with tuberculous peritonitis (n=48) or epithelial ovarian malignancy (n=370) at Samsung Medical Center from January 2000 to October 2009 were retrospectively reviewed.

RESULTS

Median serum CA-125 level in the epithelial ovarian cancer group was significantly higher than that in the tuberculous peritonitis group (p ≤ 0.01). Only one patient (2.1%) in the tuberculous peritonitis group had a serum CA-125 level over 2000 U/mL. However, 109 patients (29.5%) in the epithelial ovarian cancer group had a serum CA-125 level over 2000 U/mL. At the CA-125 ranges of 400 to 599 and 600 to 799, the proportions of those with tuberculous peritonitis were 24% and 21.9%, respectively. At a serum CA-125 level over 1000 U/mL, however, the proportion of tuberculous peritonitis was much lower (2.1%).

CONCLUSION

Tuberculous peritonitis should be considered in the evaluation of female patients with ascites and high serum CA-125.

摘要

目的

结核分枝杆菌在韩国流行。由于结核性腹膜炎的特征是腹水、腹痛、腹部肿块和血清 CA-125 升高，因此可能与卵巢恶性肿瘤混淆。本研究旨在评估血清 CA-125 水平在分枝杆菌流行地区结核性腹膜炎和卵巢恶性肿瘤鉴别诊断中的意义。

材料与方法

回顾性分析 2000 年 1 月至 2009 年 10 月在三星医疗中心诊断为结核性腹膜炎（n=48）或上皮性卵巢恶性肿瘤（n=370）的患者的病历。

结果

上皮性卵巢癌组的中位血清 CA-125 水平明显高于结核性腹膜炎组（p ≤ 0.01）。结核性腹膜炎组仅有 1 例（2.1%）患者的血清 CA-125 水平超过 2000 U/ml。然而，上皮性卵巢癌组中有 109 例（29.5%）患者的血清 CA-125 水平超过 2000 U/ml。在 CA-125 范围为 400 至 599 和 600 至 799 时，结核性腹膜炎的比例分别为 24%和 21.9%。然而，在血清 CA-125 水平超过 1000 U/ml 时，结核性腹膜炎的比例要低得多（2.1%）。