Meibodi Naser Tayyebi, Nahidi Yalda, Meshkat Zahra, Esmaili Habibollah, Gharib Masoumeh, Gholoobi Aida
Department of Pathology, Mashhad University of Medical Sciences, Mashhad, Iran.
Indian J Dermatol. 2013 Jul;58(4):326. doi: 10.4103/0019-5154.113949.
Seborrheic keratosis (SK) is a benign epidermal tumor of unknown etiology. Because of its wart-like morphology, Human papillomaviruses (HPVs) have been suggested as a possible causative agent. Viral involvement, however, has not been confirmed yet despite research and the association between HPVs and seborrheic keratosis has not been studied among Iranian population by PCR.
The aim of this case-control study was to evaluate the presence of HPVs DNA in non-genital SK by PCR.
Fifty biopsy specimens obtained from patients with non-genital SK and 50 controls were analyzed using polymerase chain reaction (PCR).
No HPVs DNA was detected by PCR within the tissue extracts from paraffin-embedded SK samples, while one of the controls was HPVs DNA positive. The age range of the patients was 20 to 82 yrs (mean = 52). Twenty-eight patients (56%) were males and 22 patients (44%) were females. The most common anatomic site was the face. Histopathologic changes due to viral infection such as koilocytosis (10%), dyskeratosis (66%), mitosis (28%), and parakeratosis (88%) were evident within the lesions. The most common histologic type was acanthotic type.
Our results showed that there is no association between HPVs and seborrheic keratosis in investigated subjects.
脂溢性角化病（SK）是一种病因不明的良性表皮肿瘤。由于其疣状形态，有人提出人乳头瘤病毒（HPV）可能是致病因素。然而，尽管进行了研究，但病毒感染尚未得到证实，并且在伊朗人群中尚未通过聚合酶链反应（PCR）研究HPV与脂溢性角化病之间的关联。
本病例对照研究的目的是通过PCR评估非生殖器SK中HPV DNA的存在情况。
对50例非生殖器SK患者和50例对照者的活检标本进行聚合酶链反应（PCR）分析。
在石蜡包埋的SK样本的组织提取物中，PCR未检测到HPV DNA，而1例对照者HPV DNA呈阳性。患者年龄范围为20至82岁（平均=52岁）。28例患者（56%）为男性，22例患者（44%）为女性。最常见的解剖部位是面部。病变内可见病毒感染引起的组织病理学变化，如空泡细胞形成（10%）、角化不良（66%）、有丝分裂（28%）和不全角化（88%）。最常见的组织学类型是棘层肥厚型。
我们的结果表明，在所研究的对象中，HPV与脂溢性角化病之间没有关联。
