a Division of Cardiothoracic Surgery, Departments of.
Radiat Res. 2013 Sep;180(3):247-58. doi: 10.1667/RR3292.1. Epub 2013 Aug 6.
The objective of this study was to determine whether radiation-induced injury to the heart after 10 Gy total body irradiation (TBI) is direct or indirect. Young male WAG/RijCmcr rats received a 10 Gy single dose using TBI, upper hemi-body (UHB) irradiation, lower hemi-body (LHB) irradiation, TBI with the kidneys shielded or LHB irradiation with the intestines shielded. Age-matched, sham-irradiated rats served as controls. The lipid profile, kidney injury, heart and liver morphology and cardiac function were determined up to 120 days after irradiation. LHB, but not UHB irradiation, increased the risk factors for cardiac disease as well as the occurrence of cardiac and kidney injury in a way that was quantitatively and qualitatively similar to that observed after TBI. Shielding of the kidneys prevented the increases in risk factors for cardiac disease. Shielding of the intestines did not prevent the increases in risk factors for cardiac disease. There was no histological evidence of liver injury 120 days after irradiation. Injury to the heart from irradiation appears to be indirect, supporting the notion that injury to abdominal organs, principally the kidneys, is responsible for the increased risk factors for and the occurrence of cardiac disease after TBI and LHB irradiation.
本研究旨在确定 10 Gy 全身照射（TBI）后心脏的辐射损伤是直接的还是间接的。年轻雄性 WAG/RijCmcr 大鼠接受单次 10 Gy TBI、上半身（UHB）照射、下半身（LHB）照射、肾脏屏蔽 TBI 或肠道屏蔽 LHB 照射。年龄匹配的假照射大鼠作为对照。直到照射后 120 天，测定血脂谱、肾损伤、心脏和肝脏形态以及心脏功能。与 TBI 观察到的方式类似，LHB 照射而不是 UHB 照射增加了心脏病的危险因素以及心脏和肾脏损伤的发生。肾脏屏蔽可预防心脏病危险因素的增加。肠道屏蔽并不能预防心脏病危险因素的增加。照射 120 天后没有肝脏损伤的组织学证据。辐射对心脏的损伤似乎是间接的，这支持了这样一种观点，即腹部器官（主要是肾脏）的损伤是 TBI 和 LHB 照射后心脏病危险因素增加和发生的原因。
