Wright Trista H, Cline-Parhamovich Karen, Lajoie Dawn, Parsons Laura, Dunn Mark, Ferslew Kenneth E
Toxicology, William L. Jenkins Forensic Center, East Tennessee State University, PO Box 70422, Johnson City, TN.
J Forensic Sci. 2013 Nov;58(6):1558-62. doi: 10.1111/1556-4029.12260. Epub 2013 Aug 6.
Two deaths involving 3, 4-methylenedioxypyrovalerone (MDPV) are reported. MDPV is a synthetic cathinone stimulant found in "bath salts" with neurological and cardiovascular toxicity. Biological specimens were analyzed for MDPV by GC/MS and LC/MS. A White man was found dead with signs of nausea and vomiting after repeatedly abusing bath salts during a weekend binge. Femoral venous blood and urine had MDPV concentrations of 39 ng/mL and 760 ng/mL. The second fatality was a White man with a history of drug and bath salt abuse found dead at a scene in total disarray after exhibiting fits of anger and psychotic behavior. Femoral venous blood and urine had MDPV concentrations of 130 ng/mL and 3800 ng/mL. The blood and urine MDPV concentrations are within the reported recreational concentration ranges (blood 24-241 ng/mL and urine 34-3900 ng/mL). Both decedents' deaths were attributed to relevant natural causes in a setting of MDPV abuse.
报告了两起涉及3,4-亚甲基二氧吡咯戊酮（MDPV）的死亡事件。MDPV是一种在“浴盐”中发现的合成卡西酮兴奋剂，具有神经和心血管毒性。通过气相色谱/质谱联用仪（GC/MS）和液相色谱/质谱联用仪（LC/MS）对生物样本进行MDPV分析。一名白人男性在周末狂欢期间反复滥用浴盐后，被发现死于恶心和呕吐症状。股静脉血和尿液中的MDPV浓度分别为39纳克/毫升和760纳克/毫升。第二起死亡事件的死者是一名有药物和浴盐滥用史的白人男性，在出现愤怒发作和精神病行为后，被发现死于一片混乱的现场。股静脉血和尿液中的MDPV浓度分别为130纳克/毫升和3800纳克/毫升。血液和尿液中的MDPV浓度在报告的娱乐性使用浓度范围内（血液24 - 241纳克/毫升，尿液34 - 3900纳克/毫升）。两名死者的死亡均归因于在MDPV滥用情况下的相关自然原因。
