Belorusov O S, Goriaĭnov V A, Tsygankova S T, Akimova N I
Khirurgiia (Mosk). 1990 May(5):8-11.
The frequency of the development of rejection crises in the early postoperative period in 32 recipients of allogeneic kidneys from alive related donors was analysed depending on the histocompatibility according to the antigens of the HLA-AB system and the nature of the immunosuppressant therapy. The results of the analysis showed that the frequency of rejection crises was 100% when the donor and recipient were compatible in 1-2 antigens, and 40% in compatibility according to 3-4 antigens. The incidence of rejection crises was 71.4% among patients who received the standard immunosuppressant therapy (corticosteroids + azathioprine) and 36% among those given also sandimmune. Analysis of the frequency of rejection crises according to the ABO blood group system to which the donor-recipient pair occurred, showed that rejection crises occurred most frequently among patients with A (II) blood group.
根据HLA - AB系统抗原的组织相容性和免疫抑制治疗的性质,分析了32例来自活体亲属供体的同种异体肾移植受者术后早期排斥反应危机发生的频率。分析结果显示,当供体和受体在1 - 2种抗原上相容时,排斥反应危机的频率为100%,在3 - 4种抗原相容时为40%。接受标准免疫抑制治疗(皮质类固醇 + 硫唑嘌呤)的患者中排斥反应危机的发生率为71.4%,同时使用环孢素的患者中为36%。根据供体 - 受体对所属的ABO血型系统分析排斥反应危机的频率,结果显示A型(II)血的患者中排斥反应危机最常发生。