Galman M S, Sundstrom S A, Lyttle C R
Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia 19104.
J Steroid Biochem. 1990 Jul 4;36(4):281-6. doi: 10.1016/0022-4731(90)90218-h.
The uterus of the immature rat synthesizes and secretes complement component C3 in response to estradiol treatment. This response occurs in the uterine epithelial cells and is also stimulated by several antiestrogens including tamoxifen and LY117018. The administration of a new antiestrogen ICI 164,384 blocked the estradiol as well as the antiestrogen-stimulated increases in uterine weight, epithelial cell height, C3 synthesis and C3 mRNA. ICI 164,384 demonstrated no agonist properties in terms of epithelial cell response as determined by C3 expression.
未成熟大鼠的子宫在接受雌二醇治疗后会合成并分泌补体成分C3。这种反应发生在子宫上皮细胞中，并且也受到几种抗雌激素的刺激，包括他莫昔芬和LY117018。新型抗雌激素ICI 164,384的给药阻断了雌二醇以及抗雌激素刺激引起的子宫重量、上皮细胞高度、C3合成和C3 mRNA的增加。就通过C3表达确定的上皮细胞反应而言，ICI 164,384没有表现出激动剂特性。
