Salgado Breno S, Monteiro Lidianne N, Colodel Márcia M, Figueiroa Fernanda C, Soares Luisa M, Nonogaki Suely, Rocha Rafael M, Rocha Noeme S
Departamento de Patologia, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista - UNESP, Botucatu, Brazil.
Vet Clin Pathol. 2013 Sep;42(3):382-5. doi: 10.1111/vcp.12060. Epub 2013 Aug 6.
Mammary invasive micropapillary carcinoma is a rare variant of mammary carcinoma that was recently recognized in dogs. The cytologic features and biologic behavior of such neoplasms in dogs have not yet been widely discussed in the veterinary literature. We report the clinical, cytologic, and histologic features of a canine micropapillary carcinoma in a 13-year-old female mongrel dog. The mammary region presented with extreme local pain, severe edema and erythema, and multifocal epidermal ulceration, which is typical for an inflammatory mammary carcinoma. Fine-needle aspirates were highly cellular and consisted of individual cells and papillary cell clusters with characteristics of malignant epithelial cells. Histologic examination revealed neoplastic cells arranged in small papillae without fibrovascular cores, sometimes inside clear lymphatic spaces, indicating lymphovascular invasion. Regional lymph node evaluation revealed metastatic cells. Due to deteriorating clinical condition the dog was euthanatized 5 months after mastectomy. At necropsy, metastatic neoplastic mammary cells were found in popliteal and mediastinal lymph nodes, the right femoral biceps muscle, liver, heart, lungs, and urinary bladder.
乳腺浸润性微乳头状癌是一种罕见的乳腺癌变体，最近在犬类中被发现。此类肿瘤在犬类中的细胞学特征和生物学行为在兽医文献中尚未得到广泛讨论。我们报告了一只13岁雌性杂种犬的犬微乳头状癌的临床、细胞学和组织学特征。乳腺区域表现为极度局部疼痛、严重水肿和红斑，以及多灶性表皮溃疡，这是炎性乳腺癌的典型表现。细针穿刺抽吸物细胞丰富，由单个细胞和具有恶性上皮细胞特征的乳头状细胞簇组成。组织学检查显示肿瘤细胞排列成无纤维血管核心的小乳头，有时位于透明的淋巴管腔内，提示淋巴管侵犯。区域淋巴结评估发现转移细胞。由于临床状况恶化，该犬在乳房切除术后5个月实施安乐死。尸检时，在腘窝和纵隔淋巴结、右股二头肌、肝脏、心脏、肺和膀胱中发现了转移性肿瘤乳腺细胞。
