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日粮谷氨酰胺补充可预防乙酸诱导的大鼠肠损伤后黏膜损伤，并调节肠上皮修复。

Dietary glutamine supplementation prevents mucosal injury and modulates intestinal epithelial restitution following acetic acid induced intestinal injury in rats.

机构信息

Department of Surgery, Bnai Zion Medical Center, Haifa, Israel.

Laboratory of Intestinal Adaptation and Recovery, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

出版信息

Nutr Metab (Lond). 2013 Aug 7;10:53. doi: 10.1186/1743-7075-10-53. eCollection 2013.

DOI:10.1186/1743-7075-10-53
PMID:23919638
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3750704/
Abstract

Beneficial effects of glutamine (GLN) have been described in many gastrointestinal disorders. The aim of the present study was to evaluate the preventative effect of oral GLN supplementation against acetic acid (AA) induced intestinal injury in a rat. Male Sprague-Dawley rats were divided into four experimental groups: control (CONTR) rats underwent laparotomy, control-glutamine (CONTR-GLN) rats were treated with enteral glutamine given in drinking water (2%) 48 hours before and five days following laparotomy, AA rats underwent laparotomy and injection of AA into an isolated jejunal loop, and acetic acid-glutamine (AA-GLN) rats underwent AA-induced injury and were treated with enteral GLN 48 hours before and 5 days following laparotomy. Intestinal mucosal damage (Park's injury score), mucosal structural changes, enterocyte proliferation and enterocyte apoptosis were determined five days following intestinal injury. Western blotting was used to determine p-ERK and bax protein levels. AA-induced intestinal injury resulted in a significantly increased intestinal injury score with concomitant inhibition of cell turnover (reduced proliferation and enhanced apoptosis). Treatment with dietary GLN supplementation resulted in a decreased intestinal injury score with concomitant stimulation of cell turnover (enhanced proliferation and reduced apoptosis). In conclusion, pre-treatment with oral GLN prevents mucosal injury and improves intestinal recovery following AA-induced intestinal injury in rats.

摘要

谷氨酰胺（GLN）已在许多胃肠道疾病中显示出有益作用。本研究旨在评估口服 GLN 补充对乙酸（AA）诱导的大鼠肠损伤的预防作用。雄性 Sprague-Dawley 大鼠分为四组实验：对照组（CONTR）大鼠接受剖腹术，对照谷氨酰胺（CONTR-GLN）大鼠在剖腹术前 48 小时和术后 5 天给予口服 GLN（2%）治疗，AA 大鼠接受剖腹术和乙酸注入孤立的空肠袢，AA 谷氨酰胺（AA-GLN）大鼠接受 AA 诱导的损伤并在剖腹术前 48 小时和术后 5 天给予口服 GLN 治疗。在肠损伤后 5 天，测定肠黏膜损伤（Park 损伤评分）、黏膜结构变化、肠上皮细胞增殖和肠上皮细胞凋亡。Western blot 用于测定 p-ERK 和 bax 蛋白水平。AA 诱导的肠损伤导致肠损伤评分显著增加，同时细胞更替受到抑制（增殖减少，凋亡增加）。用膳食 GLN 补充治疗可降低肠损伤评分，同时刺激细胞更替（增强增殖，减少凋亡）。结论：口服 GLN 预处理可预防 AA 诱导的大鼠肠损伤后的黏膜损伤并促进肠恢复。

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