Campistol J M, Oppenheimer F, Darnell A, Andreu J, Torras A, Revert L
Unidad de Trasplante Renal y Servicio de Nefrología, Hospital Clínic i Provincial, Barcelona.
Med Clin (Barc). 1990 May 26;94(20):761-5.
The incidence of glomerular diseases was retrospectively reviewed in our population of renal transplants performed during the period 1972-1988. Overall, 42 instances of post-transplant glomerular disease were observed in 39 patients. The most common type of glomerular disease was transplant glomerulopathy in 13 cases, followed by membranous glomerulonephritis in 8. Regarding etiology, relapse of the original nephropathy was considered to be present in 15 patients and de novo glomerular disease in the remaining 27. In our series, the incidence of clinical relapses was 12%, ranging between 75% in hemolytic-uremic syndrome and 8% in mesangiocapillary glomerulonephritis. 50% of those patients who developed glomerular disease after transplant had a loss of their grafts during the follow up period. The survival of the graft, from 6.5 years after transplant onwards, was significantly lower than that seen in the group of transplanted patients without glomerular disease.
我们回顾性分析了1972年至1988年期间进行肾移植的人群中肾小球疾病的发病率。总体而言,在39例患者中观察到42例移植后肾小球疾病。最常见的肾小球疾病类型是移植性肾小球病,共13例,其次是膜性肾小球肾炎,共8例。关于病因,15例患者被认为是原发性肾病复发,其余27例为新发肾小球疾病。在我们的系列研究中,临床复发率为12%,在溶血尿毒综合征中为75%,在系膜毛细血管性肾小球肾炎中为8%。移植后发生肾小球疾病的患者中有50%在随访期间移植肾失功。移植后6.5年起,发生肾小球疾病患者的移植肾存活率显著低于未发生肾小球疾病的移植患者组。