Fux Otta Carolina, Fiol de Cuneo Marta, Szafryk de Mereshian Paula
Rev Fac Cien Med Univ Nac Cordoba. 2013;70(1):27-30.
Polycystic ovary syndrome (PCOS), the most common gynecological endocrinopathy in women of reproductive age, is characterized by hyperandrogenism, chronic anovulation and /or polycystic ovaries. Although the cause of PCOS is still unknown, there are several hypotheses attempting to explain the primary defect; the most commonly accepted is insulin resistance. Due to its high prevalence, the patients have increased risk of developing metabolic and cardiovascular alterations. The compensatory hyperinsulinemia contributes to hyperandrogenism in different ways: by stimulating ovarian androgen synthesis and inhibiting hepatic production of sex hormone binding globulin. From the study of the intrauterine environment in recent years it has been suggested that PCOS may have an origin in utero associated with prenatal exposure to androgens. The aim of this paper is to review the main mechanisms proposed to cause the syndrome.
多囊卵巢综合征（PCOS）是育龄女性中最常见的妇科内分泌疾病，其特征为高雄激素血症、慢性无排卵和/或多囊卵巢。尽管PCOS的病因尚不清楚，但有几种假说来解释其原发性缺陷；最被广泛接受的是胰岛素抵抗。由于其高患病率，患者发生代谢和心血管改变的风险增加。代偿性高胰岛素血症通过不同方式导致高雄激素血症：刺激卵巢雄激素合成并抑制肝脏性激素结合球蛋白的产生。近年来对子宫内环境的研究表明，PCOS可能起源于子宫内，与产前暴露于雄激素有关。本文旨在综述引发该综合征的主要机制。
