Brauer M, Towner R A, Foxall D L
Guelph-Waterloo Center for Graduate Work in Chemistry, University of Guelph, Ontario, Canada.
Magn Reson Imaging. 1990;8(4):459-65. doi: 10.1016/0730-725x(90)90054-6.
Magnetic resonance imaging techniques were used to investigate the response of the liver of the rat in situ to a toxicological challenge by carbon tetrachloride. Proton images were taken as transverse slices through the rat before and after intraperitoneal administration of the hepatotoxin. Two to three hours after carbon tetrachloride was given, a region of high proton signal intensity was observed where the portal vein enters the liver. Sodium-23 images were also taken, and a region of high sodium intensity was observed in the same location within the liver as the increased proton intensity. The results suggest that acute administration of carbon tetrachloride induces localized liver damage in the region where the hepatotoxin first enters the liver. This liver damage is manifest as edema with a buildup of sodium ion and water, which can be readily detected by sodium-23 and proton NMR imaging techniques, respectively.
采用磁共振成像技术研究了大鼠原位肝脏对四氯化碳毒理学挑战的反应。在腹腔注射肝毒素前后，以横向切片的方式对大鼠进行质子成像。给予四氯化碳两到三小时后，在门静脉进入肝脏的部位观察到一个质子信号强度较高的区域。还进行了钠-23成像，在肝脏内与质子强度增加相同的位置观察到一个钠强度较高的区域。结果表明，急性给予四氯化碳会在肝毒素首次进入肝脏的区域诱发局部肝损伤。这种肝损伤表现为水肿，伴有钠离子和水的积聚，分别可通过钠-23和质子核磁共振成像技术轻易检测到。
