卤代烃诱导肝损伤的体内质子核磁共振成像与波谱研究。
In vivo proton nuclear magnetic resonance imaging and spectroscopy studies of halocarbon-induced liver damage.
作者信息
Brauer M, Towner R A, Renaud I, Janzen E G, Foxall D L
机构信息
Guelph-Waterloo Center for Graduate Work in Chemistry, University of Guelph, Ontario, Canada.
出版信息
Magn Reson Med. 1989 Feb;9(2):229-39. doi: 10.1002/mrm.1910090208.
Proton magnetic resonance imaging and localized NMR spectroscopy were used to study the rat liver in situ. Respiratory gating was used in both the imaging and the localized spectroscopy studies to control for the movement of the upper abdomen of the rat during breathing. After administration of carbon tetrachloride, bromotrichloromethane, or halothane, localized regions of high proton signal intensity were observed in the NMR images of the liver. Localized (VOSY) proton NMR spectra from within these regions indicated that the increase in a signal intensity was due to a longer T2 relaxation time for the water resonance, indicating acute edema in the region of tissue damage.
利用质子磁共振成像和局部核磁共振波谱技术对大鼠肝脏进行原位研究。在成像和局部波谱研究中均采用呼吸门控技术，以控制大鼠呼吸过程中上腹部的移动。给予四氯化碳、溴三氯甲烷或氟烷后，在肝脏的核磁共振图像中观察到高质子信号强度的局部区域。来自这些区域的局部（VOSY）质子核磁共振波谱表明，信号强度的增加是由于水共振的T2弛豫时间延长，这表明组织损伤区域存在急性水肿。
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