Croes Kim, De Coster Sam, De Galan Sandra, Morrens Bert, Loots Ilse, Van de Mieroop Els, Nelen Vera, Sioen Isabelle, Bruckers Liesbeth, Nawrot Tim, Colles Ann, Den Hond Elly, Schoeters Greet, van Larebeke Nicolas, Baeyens Willy, Gao Yue
Free University of Brussels (VUB), Department of Analytical and Environmental Chemistry (ANCH), Pleinlaan 2, 1050 Brussels, Belgium.
Ghent University Hospital, Study Centre for Carcinogenesis and Primary Prevention of Cancer, De Pintelaan 185, 9000 Ghent, Belgium.
Int J Hyg Environ Health. 2014 Mar;217(2-3):239-47. doi: 10.1016/j.ijheh.2013.06.004. Epub 2013 Jun 28.
Due to possible health risks, quantification of mercury accumulation in humans was included in the Flemish biomonitoring programmes FLEHS I (2002-2006) and FLEHS II (2007-2011). The general objective of FLEHS I was to assess regional exposure levels in order to link possible differences in these internal exposure levels to different types of local environmental pressure. Therefore, Hg and MMHg (methylmercury) were only measured in pooled blood samples per region and per age class. In FLEHS II, mercury concentrations were measured in hair of each participant. About 200 adolescents and 250 mothers (reference group) and two times 200 adolescents (2 hotspots) were screened. The main objectives of the FLEHS II study were: (1) to determine reference levels of mercury in hair for Flanders; (2) to assess relations between mercury exposure and possible sources like fish consumption; (3) to assess dose-effect relations between mercury exposure and health effect markers. The results showed that mercury concentrations in the Flemish population were rather low compared to other studies. Mercury levels in the Flemish populations were strongly related to the age of the participants and consumption of fish. Significant negative associations were observed between mercury in hair and asthma, having received breast feeding as a newborn, age at menarche in girls, allergy for animals and free testosterone levels. Significant correlations were also observed between mercury in hair and genes JAK2, ARID4A, Hist1HA4L (boys) and HLAdrb5, PIAS2, MANN1B1, GIT and ABCA1 (girls).
由于可能存在健康风险，人体汞蓄积量的量化已被纳入弗拉芒生物监测项目FLEHS I（2002 - 2006年）和FLEHS II（2007 - 2011年）。FLEHS I的总体目标是评估区域暴露水平，以便将这些内部暴露水平的可能差异与不同类型的当地环境压力联系起来。因此，仅在每个区域和每个年龄组的混合血样中测量汞和甲基汞。在FLEHS II中，测量了每位参与者头发中的汞浓度。对约200名青少年和250名母亲（参照组）以及两组各200名青少年（两个热点地区）进行了筛查。FLEHS II研究的主要目标是：（1）确定弗拉芒地区头发中汞的参考水平；（2）评估汞暴露与鱼类消费等可能来源之间的关系；（3）评估汞暴露与健康效应标志物之间的剂量 - 效应关系。结果表明，与其他研究相比，弗拉芒人群中的汞浓度相当低。弗拉芒人群中的汞水平与参与者的年龄和鱼类消费密切相关。头发中的汞与哮喘、新生儿期接受母乳喂养、女孩初潮年龄、动物过敏和游离睾酮水平之间存在显著的负相关。头发中的汞与基因JAK2、ARID4A、Hist1HA4L（男孩）以及HLAdrb5、PIAS2、MANN1B1、GIT和ABCA1（女孩）之间也存在显著相关性。
