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5-取代的2-(N,N-二烷基氨基乙基)氨基-和2-N-甲基哌嗪基-1,3,4-噻二唑的合成及药理活性

Synthesis and pharmacological activity of 5-substituted 2-(N,N-dialkylaminoethyl)amino- and 2-N-methylpiperazinyl-1,3,4-thiadiazoles.

作者信息

Lalezari I, Shafiee A, Badaly A, Salimi M M, Khoyi M A, Abtahi F, Zarrindast M R

出版信息

J Pharm Sci. 1975 Jul;64(7):1250-2. doi: 10.1002/jps.2600640732.

DOI:10.1002/jps.2600640732
PMID:239205
Abstract

5-Substituted 2-amino-1,3,4-thiadiazoles were transformed to their corresponding 2-bromo derivatives. The reaction of the 5-substituted 2-bromo-1,3,4-thiadiazoles with N,N-dialkylaminoethylamines or N-methylpiperazine afforded the corresponding amino-1,3,4-thiadiazole derivatives. All prepared compounds displayed antihistaminic, anticholinergic, and norepinephrine-potentiating activities.

摘要

5-取代的2-氨基-1,3,4-噻二唑被转化为其相应的2-溴衍生物。5-取代的2-溴-1,3,4-噻二唑与N,N-二烷基氨基乙胺或N-甲基哌嗪反应得到相应的氨基-1,3,4-噻二唑衍生物。所有制备的化合物均表现出抗组胺、抗胆碱能和去甲肾上腺素增强活性。

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