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Response to the letter to the editor by Susan Thorpe et al.: how predictive are in vitro assays for cytokine release syndrome in vivo? A comparison of methods reveals worrying differences in sensitivity and frequency of response.

作者信息

Wolf Babette, Morgan Hannah, Brennan Frank, Krieg Jennifer, Gani Zaahira, Jones Stewart, Kiessling Andrea

机构信息

Biologics Safety and Disposition, Preclinical Safety, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Werk Klybeck, Basel, Switzerland.

出版信息

Cytokine. 2013 Oct;64(1):473-5; discussion 476. doi: 10.1016/j.cyto.2013.07.014. Epub 2013 Aug 3.

DOI:10.1016/j.cyto.2013.07.014
PMID:23921146
Abstract
摘要

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引用本文的文献

1
Cytokine release assays for the prediction of therapeutic mAb safety in first-in man trials--Whole blood cytokine release assays are poorly predictive for TGN1412 cytokine storm.在首次人体试验中用于预测治疗性单克隆抗体安全性的细胞因子释放试验——全血细胞因子释放试验对TGN1412细胞因子风暴的预测性较差。
J Immunol Methods. 2015 Sep;424:43-52. doi: 10.1016/j.jim.2015.04.020. Epub 2015 May 7.