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Hypotonic treatment leads to chromosomal aberrations but not to sister-chromatid exchanges in human lymphocytes.

作者信息

Kalweit S, Nowak C, Obe G

机构信息

Freie Universität Berlin, Institut für Genetik, Germany.

出版信息

Mutat Res. 1990 Sep;245(1):5-9. doi: 10.1016/0165-7992(90)90017-e.

DOI:10.1016/0165-7992(90)90017-e
PMID:2392128
Abstract

Human peripheral lymphocytes were isolated from whole blood and exposed to culture medium of reduced osmolality. This hypotonic treatment led to a significant increase in the frequencies of chromosomal aberrations when the osmolality was reduced to 60 mOsm/kg H2O and below. Maximum damage occurred when the hypotonic treatment was done 27 or 30 h after starting the cultures. We also looked for the induction of sister-chromatid exchanges (SCE) by hypotonic culture conditions, but the SCE frequencies were not influenced.

摘要

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