Chan C Stanley, Saedi Nazanin, Mickle Clinzo, Dover Jeffrey S
SkinCare Physicians, Chestnut Hill, Massachusetts.
Lasers Surg Med. 2013 Sep;45(7):405-9. doi: 10.1002/lsm.22162. Epub 2013 Aug 7.
Combination laser treatments can potentially increase the effectiveness of treatment without the additional downtime associated with another procedure.
To assess the effectiveness and safety of combining non-ablative fractional treatments with optimized intense pulsed light.
Ten subjects (Group A) received full face treatments with a non-ablative fractional either followed or preceded by an optimized intense pulsed light source. Twenty-six subjects (Group B) received only full face treatments with the same non-ablative, fractional laser device.
For Group A, the overall average Fitzpatrick Wrinkle Scale for all patients improved from 6.3 ± 1.1 at baseline to 5.9 ± 0.8 one month following one treatment for an average improvement of 0.4 ± 0.6 (P < 0.10 paired t-test n = 9). The average pigment improvement score was 1.8 ± 0.9 on a 4-point scale. In Group B, the average Fitzpatrick Wrinkle Scale improved from 6.0 ± 1.6 at baseline to 5.2 ± 1.4 at 3 months for an average improvement of 0.8 ± 0.7 (P < 0.001, n = 26 paired t-test). The average pigment improvement score was 1.4 ± 1.0 (P < 0.001, t-test, n = 26). Adverse events were similar in the two groups.
The combination of an optimized intense pulsed light source with a non-ablative fractional laser during the same treatment session is safe and effective.
联合激光治疗有可能提高治疗效果，且不会因额外的手术而增加停工期。
评估非剥脱性分次治疗联合优化强脉冲光的有效性和安全性。
10名受试者（A组）接受了非剥脱性分次全脸治疗，治疗顺序为先使用优化强脉冲光源或后使用优化强脉冲光源。26名受试者（B组）仅接受了相同的非剥脱性分次激光设备的全脸治疗。
对于A组，所有患者的整体平均菲茨帕特里克皱纹量表评分从基线时的6.3±1.1改善至一次治疗后1个月的5.9±0.8，平均改善0.4±0.6（配对t检验，P<0.10，n=9）。色素改善平均评分为4分制下的1.8±0.9。在B组中，平均菲茨帕特里克皱纹量表评分从基线时的6.0±1.6改善至3个月时的5.2±1.4，平均改善0.8±0.7（配对t检验，P<0.001，n=26）。色素改善平均评分为1.4±1.0（t检验，P<0.001，n=26）。两组的不良事件相似。
在同一治疗疗程中，优化强脉冲光源与非剥脱性分次激光联合使用是安全有效的。
