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腺苷益生元类似物的化学结构。

Chemical structure of a prebiotic analog of adenosine.

作者信息

Maurel M C, Convert O

机构信息

Institut Jacques Monod du CNRS, Paris, France.

出版信息

Orig Life Evol Biosph. 1990;20(1):43-8. doi: 10.1007/BF01808058.

DOI:10.1007/BF01808058
PMID:2392317
Abstract

Upon heating a dry mixture of ribose and adenine, condensation products are formed. They were identified as isomers of N6-ribosyl-adenine (Fuller, Sanchez and Orgel, 1972). Due to the current interest in nucleotide analogs as potential constituents of primitive RNA catalysts, the products were further characterized by mass spectroscopy and proton NMR. Our results fully substantiate the previous proposals.

摘要

加热核糖和腺嘌呤的干燥混合物时,会形成缩合产物。它们被鉴定为N6-核糖基腺嘌呤的异构体(富勒、桑切斯和奥格尔,1972年)。由于目前对核苷酸类似物作为原始RNA催化剂潜在成分的关注,这些产物通过质谱和质子核磁共振进一步表征。我们的结果充分证实了先前的提议。

相似文献

1
Chemical structure of a prebiotic analog of adenosine.腺苷益生元类似物的化学结构。
Orig Life Evol Biosph. 1990;20(1):43-8. doi: 10.1007/BF01808058.
2
Methylation of adenosine in strongly alkaline medium: Preparation and Properties of o'-methyl derivatives of adenosine and N6-methyladenosine.
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3
Catalysis by a prebiotic nucleotide analog of histidine.由组氨酸的一种益生元核苷酸类似物催化。
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4
N6-substituted adenine derivatives and RNA primitive catalysts.N6-取代腺嘌呤衍生物与RNA原始催化剂。
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5
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Reaction of mucochloric acid with adenosine: formation of 8-(N6-adenosinyl)ethenoadenosine derivatives.粘氯酸与腺苷的反应:8-(N6-腺苷基)乙烯腺苷衍生物的形成
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A 13C NMR study of poly(adenosine diphosphate ribose) and its monomers: evidence of alpha-(1'' leads to 2') ribofuranosy1 ribofuranoside risidue.聚(腺苷二磷酸核糖)及其单体的13C核磁共振研究:α-(1''→2')呋喃核糖基呋喃核糖苷残基的证据。
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10
Conformational studies on adenosine and its analogs by proton magnetic resonance.通过质子磁共振对腺苷及其类似物进行的构象研究。
Indian J Biochem Biophys. 1985 Feb;22(1):49-55.

引用本文的文献

1
The prebiotic role of adenine: a critical analysis.腺嘌呤的益生元作用:批判性分析
Orig Life Evol Biosph. 1995 Jun;25(1-3):83-98. doi: 10.1007/BF01581575.
2
N6-substituted adenine derivatives and RNA primitive catalysts.N6-取代腺嘌呤衍生物与RNA原始催化剂。
Orig Life Evol Biosph. 1993 Dec;23(5-6):299-306. doi: 10.1007/BF01582080.

本文引用的文献

1
Template-directed synthesis of novel, nucleic acid-like structures.新型核酸样结构的模板导向合成。
Science. 1985 May 3;228:585-7. doi: 10.1126/science.228.4699.585.
2
Conformational analysis of the sugar ring in nucleosides and nucleotides. Improved method for the interpretation of proton magnetic resonance coupling constants.核苷和核苷酸中糖环的构象分析。解释质子磁共振耦合常数的改进方法。
J Am Chem Soc. 1973 Apr 4;95(7):2333-44. doi: 10.1021/ja00788a038.
3
Studies in prebiotic synthesis. VI. Synthesis of purine nucleosides.益生元合成研究。VI. 嘌呤核苷的合成。
J Mol Biol. 1972 Jun 14;67(1):25-33. doi: 10.1016/0022-2836(72)90383-x.
4
An all-purine precursor of nucleic acids.一种核酸的全嘌呤前体。
Proc Natl Acad Sci U S A. 1988 Feb;85(4):1134-5. doi: 10.1073/pnas.85.4.1134.
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Nonenzymatic synthesis of 5-aminoimidazole ribonucleoside and recognition of its facile rearrangement.5-氨基咪唑核糖核苷的非酶促合成及其易重排的识别
Proc Natl Acad Sci U S A. 1988 Oct;85(19):7174-6. doi: 10.1073/pnas.85.19.7174.
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Template-directed oligomerization of 3-isoadenosine 5'-phosphate.
J Mol Evol. 1988;27(2):91-5. doi: 10.1007/BF02138366.
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Natural selection, protein engineering, and the last riboorganism: rational model building in biochemistry.
Cold Spring Harb Symp Quant Biol. 1987;52:53-63. doi: 10.1101/sqb.1987.052.01.009.
8
Catalysis by a prebiotic nucleotide analog of histidine.由组氨酸的一种益生元核苷酸类似物催化。
Biochimie. 1987 May;69(5):551-3. doi: 10.1016/0300-9084(87)90094-0.
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RNA catalysis and the origins of life.
J Theor Biol. 1986 Nov 21;123(2):127-49. doi: 10.1016/s0022-5193(86)80149-7.
10
The case for an ancestral genetic system involving simple analogues of the nucleotides.关于一个涉及核苷酸简单类似物的祖传遗传系统的情况。
Proc Natl Acad Sci U S A. 1987 Jul;84(13):4398-402. doi: 10.1073/pnas.84.13.4398.