Földes J, Bános C, Lakatos P, Tarján G
Semmelweis Orvostudományi Egyetem, I. sz. Belklinika, Budapest.
Orv Hetil. 1990 Jul 22;131(29):1579-82.
Synthesis of "sex-hormone binding globulin" is influenced by the thyroid hormones and its concentration in the serum may be a marker of the thyroid hormone effect at the peripheral tissue (liver) level. Compared to euthyroid controls serum "sex-hormone binding globulin" concentration is elevated in overt hyperthyroidism (141.6 +/- 37.6 vs 48.3 +/- 16.2 nmol/l; p less than 0.001), conversely, its mean level is decreased in the hypothyroid group of patients (24.9 +/- 14.8 vs 48.3 +/- 16.2; p less than 0.001). In the group of subclinical hyperthyroidism the mean value of "sex-hormone binding globulin" corresponds to that in control subjects (47.4 +/- 16.8), while its serum level is near the lower border of the normal range in subclinical hypothyroidism (33.6 +/- 6.1 vs 48.3 +/- 16.2; p less than 0.01). During thyroid hormone replacement for hypothyroidism measurement of serum "sex-hormone binding globulin" may help to assess the response of the target organs to the hormone therapy. In patients with peripheral thyroid hormone resistance serum "sex-hormone binding globulin" level is within the normal range (51.3 +/- 9.8), its determination supports the diagnosis of this disease.
“性激素结合球蛋白”的合成受甲状腺激素影响，其血清浓度可能是甲状腺激素在外周组织（肝脏）水平作用的一个标志物。与甲状腺功能正常的对照组相比，显性甲状腺功能亢进患者血清“性激素结合球蛋白”浓度升高（141.6±37.6对48.3±16.2nmol/l；p＜0.001），相反，甲状腺功能减退患者组其平均水平降低（24.9±14.8对48.3±16.2；p＜0.001）。在亚临床甲状腺功能亢进组中，“性激素结合球蛋白”的平均值与对照组相当（47.4±16.8），而在亚临床甲状腺功能减退时其血清水平接近正常范围的下限（33.6±6.1对48.3±16.2；p＜0.01）。在对甲状腺功能减退患者进行甲状腺激素替代治疗期间，测定血清“性激素结合球蛋白”可能有助于评估靶器官对激素治疗的反应。在外周甲状腺激素抵抗患者中，血清“性激素结合球蛋白”水平在正常范围内（51.3±9.8），其测定有助于支持该病的诊断。
