Gnanajothy Rosana, Umashanker Devika, Vega Maria C Franco, Wu Barry J
Department of Medicine, Yale-NewHaven Medical Center, New Haven, CT, USA.
Conn Med. 2013 Jun-Jul;77(6):335-7.
Creutzfeldt-Jakob Disease (CJD) is a fatal neurologic disorder caused by an infectious agent called a human prion protein. CJD can be classified as sporadic CJD, familial CJD, variant CJD, and iatrogenic CJD. We report a 64-year-old man diagnosed with CJD three months after cataract surgery. Although sporadic CJD is the most common type, the patient's cataract surgery elicited the possibility of an iatrogenic transmission. It is important to consider whether visual symptoms are a manifestation of sporadic CJD, rather than cataract surgery resulting in iatrogenic CJD. Preceding cataract surgeries have been reported with CJD, but there is no proven causality. This case highlights consideration of sporadic versus iatrogenic cause when seen in association with cataract surgery.
克雅氏病（CJD）是一种由人类朊蛋白这种感染性因子引起的致命性神经疾病。CJD可分为散发性CJD、家族性CJD、变异型CJD和医源性CJD。我们报告一名64岁男性，在白内障手术后三个月被诊断为CJD。虽然散发性CJD是最常见的类型，但该患者的白内障手术引发了医源性传播的可能性。重要的是要考虑视觉症状是否是散发性CJD的表现，而不是白内障手术导致医源性CJD。此前已有白内障手术后发生CJD的报道，但尚无确凿的因果关系。该病例强调了在与白内障手术相关的情况下，要考虑散发性病因与医源性病因。
