Sethi Ayesha, Sher Muhammad, Akram Muhammad Rouf, Karim Sabiha, Khiljee Sonia, Sajjad Ashif, Shah Syed Nisar Hussain, Murtaza Ghulam
Department of Pharmacy, Government College University, Faisalabad, Pakistan.
Acta Pol Pharm. 2013 Jul-Aug;70(4):597-600.
Albumin is one of the most extensively studied endogenous proteins which are used in the fabrication of drug delivery and diagnostic technologies during last 10 years. This review provides a summary of products involving the use of albumin as a drug delivery tool for getting better the pharmacokinetics of a drug by developing the targetted drug delivery systems and diagnosing the pathologies. Using albumin, following market approved products have been developed: Levemir and Victoza (antidiabetic product), Abraxane (antimetastatic breast cancer product), and Nanocoll and Albures (for lymphoscintigraphy and diagnosis of cancer and rheumatoid arthritis).
白蛋白是过去10年中用于药物递送和诊断技术制造的研究最为广泛的内源性蛋白质之一。本综述总结了涉及使用白蛋白作为药物递送工具的产品，这些产品通过开发靶向药物递送系统来改善药物的药代动力学并诊断疾病。利用白蛋白，已开发出以下市场批准产品：诺和平和诺和力（抗糖尿病产品）、艾日布林（抗转移性乳腺癌产品）以及纳米可和阿尔布雷斯（用于淋巴闪烁造影以及癌症和类风湿性关节炎的诊断）。
