Fontaine Denys
Service de neurochirurgie, hôpital Pasteur, CHU de Nice, 06000 Nice, France.
Rev Prat. 2013 Jun;63(6):805-9.
Neurosurgical treatment of pain is based on 3 concepts: 1) lesional techniques interrupt the transmission of nociceptive neural input by lesionning the nociceptive pathways (cordotomy, radicotomy...), they are indicated to treat morphine-resistant cancer pain; 2) neuromodulation techniques try to decrease pain by reinforcing inhibitory mechanisms, using chronic electrical stimulation of the nervous system (peripheral nerve stimulation, spinal cord stimulation, motor cortex stimulation...) to treat chronic neuropathic pain; 3) intrathecal infusion of analgesics (morphine, ziconotide), using implantable pumps, allows to increase their efficacy and to reduce their side effects. These techniques can improve, sometimes dramatically, patients with severe and chronic pain, refractory to all other treatments.
1)损伤性技术通过损伤伤害性神经通路(脊髓切断术、神经根切断术等)来中断伤害性神经输入的传递,适用于治疗吗啡抵抗性癌痛;2)神经调节技术试图通过增强抑制机制来减轻疼痛,利用慢性电刺激神经系统(外周神经刺激、脊髓刺激、运动皮层刺激等)来治疗慢性神经性疼痛;3)使用可植入泵鞘内输注镇痛药(吗啡、齐考诺肽)可提高其疗效并减少副作用。这些技术有时能显著改善对所有其他治疗均无效的严重慢性疼痛患者的状况。