Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.
Clin Transplant. 2013 Jul-Aug;27(4):607-12. doi: 10.1111/ctr.12179.
Stem cell-based therapy has received attention as a possible alternative to organ transplantation. The aim of this study was to assess the safety and efficacy of autologous transplantation of bone marrow (BM)-derived stromal cells in post-HCV liver cirrhosis patients.
10 × 10(6) of isolated human bone marrow (HBM)-stromal cells in 10 mL normal saline were injected in the spleen of 20 patients with end-stage liver cirrhosis guided by the ultrasonography, and then patients were followed up on monthly basis for six months.
A statistically significant decrease was detected in the total bilirubin, aspartate transaminase (AST), alanine transaminase (ALT) (p-value<0.01), prothrombin time (PT), and international normalized ratio (INR) levels (p-value<0.05), while a statistically significant increase in the albumin and PC (p-value<0.05) after follow-up.
This study suggested the safety, feasibility, and efficacy of the intrasplenic injection of autologous BM stromal cells in improving liver function in Egyptian patients with cirrhosis.
干细胞治疗作为器官移植的替代方法受到了关注。本研究旨在评估自体骨髓（BM）来源基质细胞移植治疗丙型肝炎后肝硬化患者的安全性和疗效。
在超声引导下，将 10 毫升生理盐水中分离的 10×10^6 个人类骨髓（HBM）基质细胞注入 20 例终末期肝硬化患者的脾脏中，然后对患者进行为期 6 个月的每月随访。
随访后总胆红素、天门冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）（p 值<0.01）、凝血酶原时间（PT）和国际标准化比值（INR）水平显著降低（p 值<0.05），而白蛋白和 PC 显著升高（p 值<0.05）。
本研究表明，自体骨髓基质细胞脾内注射治疗埃及肝硬化患者肝功能的安全性、可行性和有效性。
