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Metabolism of food derived mutagens and 2-acetylaminofluorene by purified rabbit and cDNA expressed human cytochromes P450.

作者信息

McManus M E, Burgess W M, Veronese M E, Felton J S, Knize M G, Snyderwine E G, Quattrochi L C, Tukey R H

机构信息

Department of Clinical Pharmacology, School of Medicine, Flinders University, Bedford Park, SA, Australia.

出版信息

Prog Clin Biol Res. 1990;340E:139-47.

PMID:2392457
Abstract
摘要

相似文献

1
Metabolism of food derived mutagens and 2-acetylaminofluorene by purified rabbit and cDNA expressed human cytochromes P450.纯化的兔细胞色素P450和cDNA表达的人细胞色素P450对食物源性诱变剂及2-乙酰氨基芴的代谢作用。
Prog Clin Biol Res. 1990;340E:139-47.
2
Role of recombinant cytochromes P4501A1 and P4501A2 in the metabolism and genotoxicity of food derived mutagens.重组细胞色素P4501A1和P4501A2在食物源性诱变剂的代谢和遗传毒性中的作用。
Prog Clin Biol Res. 1990;340E:127-37.
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Preferential activation and genotoxicity of food derived heterocyclic amine mutagens by recombinant cytochrome P4501A2.重组细胞色素P4501A2对食物来源的杂环胺诱变剂的优先激活作用及遗传毒性
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Developmental pattern of 3-methylcholanthrene-inducible mutagenic activation of N-2-fluorenylacetamide, 2-fluorenamine, and 2,4-diaminoanisole in the rabbit.3-甲基胆蒽诱导的兔体内N-2-芴基乙酰胺、2-芴胺和2,4-二氨基苯甲醚诱变激活的发育模式
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Catalysis of divergent pathways of 2-acetylaminofluorene metabolism by multiple forms of cytochrome P-450.多种形式的细胞色素P-450催化2-乙酰氨基芴代谢的不同途径。
Cancer Res. 1980 Dec;40(12):4456-9.
6
Metabolism of 2-amino-alpha-carboline. A food-borne heterocyclic amine mutagen and carcinogen by human and rodent liver microsomes and by human cytochrome P4501A2.2-氨基-α-咔啉的代谢。一种由人和啮齿动物肝脏微粒体以及人细胞色素P4501A2代谢的食源性杂环胺诱变剂和致癌物。
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Construction of a human cytochrome P450 1A1: rat NADPH-cytochrome P450 reductase fusion protein cDNA and expression in Escherichia coli, purification, and catalytic properties of the enzyme in bacterial cells and after purification.人细胞色素P450 1A1：大鼠NADPH-细胞色素P450还原酶融合蛋白cDNA的构建及其在大肠杆菌中的表达、纯化，以及该酶在细菌细胞内和纯化后的催化特性
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Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.人细胞色素P-450 1B1对多种化学致癌物的激活作用。
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Immunochemical study on the contributions of two molecular species of microsomal cytochrome P-450 to the metabolism of 2-acetylaminofluorene by rat liver microsomes.
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Deacetylation to 2-aminofluorene as a major initial reaction in the microsomal metabolism of 2-acetylaminofluorene to mutagenic products in preparations from rabbit lung and liver.
Cancer Res. 1985 Nov;45(11 Pt 2):5859-66.

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