Chemical stability of terbutaline sulfate injection after diluting with 0.9% sodium chloride injection when stored at room temperature in polyvinylchloride bags.

The stability of terbutaline sulfate (0.1 mg/mL) in 0.9% sodium chloride injection was studied at 25 deg C when stored in polyvinylchloride bags, using a stability-indicating high-performance liquid chromatographic assay method. The concentrations of the drug were directly related to peak heights, and percent relative standard deviation based on five injections was 1.0. The drug decomposed when boiled after adding sodium hydroxide, and the products of decomposition did not interfere with the assay procedure. The injection did not lose any potency after 23 days of storage at 25 deg C, and the pH value of 4.3 did not change. The physical appearance of the injection remained clear throughout the study period.