Oien R F, Akesson N, Forssell H
Bleking Wound Healing Center, Kalskrona, Sweden.
J Wound Care. 2013 Aug;22(8):442-4, 446-7. doi: 10.12968/jowc.2013.22.8.442.
To assess health-related quality of life (HRQoL) in an unselected patient population with hard-to-heal ulcers from baseline through healing and at follow-up 6 months after healing.
Fifty patients were recruited and the sex and age of the patient and the ulcer aetiology, duration, and size were recorded. The generic instrument EQ-5D was used for two purposes. The first was to investigate the feasibility of this instrument for assessing HRQoL in this patient group. The second was to see if the EQ-5D results would add information to the Swedish Registry of Ulcer Treatment (RUT), a national quality registry which includes variables for pain, disturbed sleep, and mobility.
We found a significant difference in HRQoL between patients with an open ulcer and those with a healed ulcer (p=0.02), but no significant difference between patients with a just-healed ulcer and patients at follow-up six months after ulcer healing (p=0.08). Sex, age, and length of ulcer duration at inclusion did not influence HRQoL (p=0.55, p=0.4, and p=0.9, respectively). Ulcer size seemed to influence HRQoL, though not significantly (p=0.07).
This study confirms that HRQoL was improved after ulcer healing. Pain, as one of the five constructs measured by the EQ-5D, was significantly associated with open ulcers. The results from the EQ-5D questionnaire were hard to interpret in terms of capturing HRQoL in this unselected patient population. Despite some limitations, we consider that the simplicity of EQ-5D could make it feasible to use in the clinical setting. However, the results from EQ-5D did not add consistent information to RUT; therefore, this questionnaire will not be included in the registry.
评估未经挑选的难愈合溃疡患者群体从基线期至溃疡愈合以及愈合后6个月随访期间的健康相关生活质量（HRQoL）。
招募了50名患者，并记录了患者的性别、年龄以及溃疡的病因、持续时间和大小。通用工具EQ-5D用于两个目的。第一个目的是研究该工具用于评估该患者群体HRQoL的可行性。第二个目的是查看EQ-5D结果是否会为瑞典溃疡治疗登记处（RUT）提供补充信息，RUT是一个国家质量登记处，其中包括疼痛、睡眠障碍和活动能力等变量。
我们发现开放性溃疡患者与愈合性溃疡患者之间的HRQoL存在显著差异（p=0.02），但刚愈合溃疡的患者与溃疡愈合后6个月随访的患者之间无显著差异（p=0.08）。纳入时的性别、年龄和溃疡持续时间并未影响HRQoL（分别为p=0.55、p=0.4和p=0.9）。溃疡大小似乎对HRQoL有影响，尽管不显著（p=0.07）。
本研究证实溃疡愈合后HRQoL得到改善。疼痛作为EQ-5D所测量的五个维度之一，与开放性溃疡显著相关。在这个未经挑选的患者群体中，EQ-5D问卷的结果在捕捉HRQoL方面难以解释。尽管存在一些局限性，但我们认为EQ-5D的简单性使其在临床环境中使用具有可行性。然而，EQ-5D的结果并未为RUT提供一致的补充信息；因此，该问卷将不纳入登记处。
