Institute of Chronic Illnesses, Incorporation, Silver Spring, MD, USA.
Transl Neurodegener. 2013 Aug 8;2(1):17. doi: 10.1186/2047-9158-2-17.
Autism spectrum disorder (ASD) is a neurological disorder in which a significant number of children experience a developmental regression characterized by a loss of previously-acquired skills and abilities. Loss of neurological function in ASD, as observed in affected children who have regressed, can be explained as neurodegeneration. Although there is research evidence of neurodegeneration or progressive encephalopathy in ASD, the issue of neurodegeneration in ASD is still under debate. Evidence of neurodegeneration in the brain in ASD includes: (1) neuronal cell loss, (2) activated microglia and astrocytes, (3) proinflammatory cytokines, (4) oxidative stress, and (5) elevated 8-oxo-guanosine levels. The evidence from this review suggests that neurodegeneration underlies the loss of neurological function in children with ASD who have experienced regression and loss of previously acquired skills and abilities, and that research into treatments to address the issue of neurodegeneration in ASD are warranted.
自闭症谱系障碍 (ASD) 是一种神经发育障碍，大量儿童表现出发育倒退的特征，表现为先前获得的技能和能力丧失。退行性自闭症儿童观察到的神经功能丧失可以解释为神经退行性变。尽管有研究证据表明 ASD 存在神经退行性变或进行性脑病，但 ASD 中神经退行性变的问题仍存在争议。ASD 大脑中神经退行性变的证据包括：（1）神经元细胞丢失，（2）激活的小胶质细胞和星形胶质细胞，（3）促炎细胞因子，（4）氧化应激，和（5）8-氧鸟嘌呤水平升高。本综述的证据表明，神经退行性变是 ASD 儿童经历退行性变和先前获得的技能和能力丧失导致神经功能丧失的基础，有必要研究针对 ASD 神经退行性变问题的治疗方法。
