Department of Applied Chemistry, Kyung Hee University, Yongin-si, Gyeonggi-do 446-701, Republic of Korea.
Chem Commun (Camb). 2013 Sep 28;49(75):8335-7. doi: 10.1039/c3cc44153a.
Individual silver nanoparticle-conjugated target protein (cTnI) molecules on gold-nanopatterned chip were selectively detected by wavelength dependent-enhanced dark field illumination. Using specific nanoparticles with unique sizes and materials, the immunotargeted nanoparticle on the chips was detected at the single-molecule level by monitoring changes in the plasmonic resonance based on wavelength dependence.
在金纳米图案化芯片上，通过波长相关增强暗场照明，选择性地检测到个体银纳米粒子结合的靶蛋白（cTnI）分子。利用具有独特尺寸和材料的特定纳米粒子，通过监测基于波长相关性的等离子体共振变化，在单分子水平上检测芯片上的免疫靶向纳米粒子。
