Landry Christine, Forest Jean-Marc, Hildgen Patrice
Montfort Hospital, Ottawa, Canada.
Int J Pharm Compd. 2005 Sep-Oct;9(5):396-8.
The oral tablet form of glycopryrrolate has been discontinued in Canada because of declining use. Alternatives include injectable glycopyrrolate, which is still on the market, and an oral solution compounded from the injectable form. The stabilities of different oral solutions of gycopyrrolate formulated from the injectable form were studied by using a high-performance liquid chromatographic technique. The 0.2 mg/mL injectable solution of glycopyrrolate was diluted 1:1 with water, simple syrup, a Hospital for Sick Children vehicle, or Ora-Plus/Ora-Sweet vehicle. After 35 days of storage, more than 90% of the original concentration of glycopyrrolate was still present in all solutions, regardless of whether the solution was kept at room temperature or refrigerated. A simple taste test indicated that Ora-Plus/Ora-Sweet solution and simple syrup were better choices as vehicles for the glycopyrrolate oral dosage form.
由于使用量下降，格隆溴铵的口服片剂剂型在加拿大已停产。替代剂型包括仍在市场上销售的注射用格隆溴铵，以及由注射剂型配制而成的口服溶液。采用高效液相色谱技术研究了由注射剂型配制的不同格隆溴铵口服溶液的稳定性。将0.2mg/mL的注射用格隆溴铵溶液用水、单糖浆、儿童医院专用溶媒或Ora-Plus/Ora-Sweet溶媒按1:1稀释。储存35天后，无论溶液是保存在室温还是冷藏条件下，所有溶液中格隆溴铵的原始浓度仍有90%以上。一项简单的口味测试表明，Ora-Plus/Ora-Sweet溶液和单糖浆作为格隆溴铵口服剂型的溶媒是更好的选择。
