Matsumoto Moeko, Kaieda Shinjiro, Honda Seiyo, Ida Hiroaki, Hoshino Tomoaki, Fukuda Takaaki
Department of Medicine, Kurume University School of Medicine.
Kurume Med J. 2013;60(1):25-8. doi: 10.2739/kurumemedj.ms61004. Epub 2013 Aug 7.
A 59-year-old woman was referred to our hospital because of severe anemia and leucopenia. Although she developed mild arthralgia without the typical symptoms of systemic lupus erythematosus (SLE), positivity for anti-Sm antibodies led us to a diagnosis of late-onset SLE. Autoimmune hemolytic anemia (AIHA) and suppression of reticulocyte production were considered to have been involved in the etiology of severe anemia. Administration of oral prednisolone (PSL) resulted in a marked improvement of the hematological abnormalities. As late-onset SLE is rare and patients tend to show the typical symptoms less frequently, close attention should be focused on latent symptoms and immunological findings.
一名59岁女性因严重贫血和白细胞减少症转诊至我院。尽管她出现了轻度关节痛，但无系统性红斑狼疮（SLE）的典型症状，抗Sm抗体阳性使我们诊断为迟发性SLE。自身免疫性溶血性贫血（AIHA）和网织红细胞生成受抑制被认为与严重贫血的病因有关。口服泼尼松龙（PSL）治疗使血液学异常明显改善。由于迟发性SLE罕见，患者出现典型症状的频率较低，因此应密切关注潜在症状和免疫学检查结果。
