Gupta Vishnu D
Pharmaceutics Division, University of Houston, Houston, Texas.
Int J Pharm Compd. 2005 Nov-Dec;9(6):484-6.
The stability of perphenazine in oral liquid dosage forms was studied by means of a stability-indicating high-performance liquid chromatography assay method that was developed in our laboratory. There was a direct relationship between the peak heights and the concentrations, with an r value of 0.998. The percent relative standard deviation based on five injections was 0.6. The products of decomposition and excipients present in the dosage forms did not interfere with the developed assay method. The dosage forms were stable for only 30 days when stored in amber-colored glass bottles at room temperature. The pH value of the mixtures remained constant at 3.7 after 90 days of storage, and the physical appearance of the mixtures did not change. The beyond-use date of 30 days is recommended for this procduct.
通过我们实验室开发的一种稳定性指示高效液相色谱分析方法，研究了奋乃静在口服液体制剂中的稳定性。峰高与浓度之间存在直接关系，相关系数r为0.998。基于五次进样的相对标准偏差百分比为0.6。剂型中存在的分解产物和辅料不干扰所开发的分析方法。当在室温下储存在琥珀色玻璃瓶中时，这些剂型仅在30天内稳定。储存90天后，混合物的pH值保持在3.7不变，混合物的外观也没有变化。建议该产品的有效期为30天。
