Varol Füsun, Uzunoğlu Renginar, Erbaş Hakan, Süt Necdet, Sayın Cenk
Department of Obstetrics & Gynecology, Faculty of Medicine, Trakya University, Edirne, Turkey
Department of Obstetrics & Gynecology, Faculty of Medicine, Trakya University, Edirne, Turkey.
Clin Appl Thromb Hemost. 2015 Apr;21(3):285-8. doi: 10.1177/1076029613498816. Epub 2013 Aug 7.
BACKGOUND/AIM: Preeclampsia (PE) is a multisystem disease resulting in high maternal-fetal morbidity and mortality. The aim of the study was to investigate antiangiogenesis-associated alterations in antiapoptotic and antioxidative proteins in PE.
Of the 46 patients with PE, 25 (54.3%) were with gestational hypertension (GH), 12 (26%) were with mild, and 9 (19.5%) were with severe PE. The serum levels of vascular endothelial growth factor receptor 1 (VEGFR-1), heme oxygenase 1 (HO-1), and B-cell lymphoma/leukemia (Bcl-2) levels were measured by enzyme-linked immunosorbent assay.
In the severe PE group, the VEGFR-1 serum levels (27.3 ± 16.8 vs 13.3 ± 10.7 ng/mL, P = .023) were higher, but the Bcl-2 levels (1.5 ± 0.2 vs 2.1 ± 1.7 ng/mL, P = .047) were lower than the levels in the GH-mild PE group (P = .047). Also, VEGFR-1/Bcl-2 ratio in the severe PE group was significantly higher (P = .003) than the ratio in the GH-mild PE group.
The Bcl-2 and HO-1 proteins seem to have important roles in the antiangiogenic environment of preeclampsia.
背景/目的：子痫前期（PE）是一种多系统疾病，可导致母婴高发病率和死亡率。本研究旨在调查子痫前期中抗血管生成相关的抗凋亡和抗氧化蛋白的改变。
46例子痫前期患者中，25例（54.3%）合并妊娠高血压（GH），12例（26%）为轻度子痫前期，9例（19.5%）为重度子痫前期。采用酶联免疫吸附测定法检测血管内皮生长因子受体1（VEGFR-1）、血红素加氧酶1（HO-1）和B细胞淋巴瘤/白血病（Bcl-2）的血清水平。
重度子痫前期组的VEGFR-1血清水平（27.3±16.8 vs 13.3±10.7 ng/mL，P = 0.0（此处原文有误，根据前文推测应为0.023）23）较高，但Bcl-2水平（1.5±0.2 vs 2.1±1.7 ng/mL，P = 0.047）低于GH-轻度子痫前期组（P = 0.047）。此外，重度子痫前期组的VEGFR-1/Bcl-2比值显著高于GH-轻度子痫前期组（P = 0.003）。
Bcl-2和HO-1蛋白似乎在子痫前期的抗血管生成环境中起重要作用。
