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小鼠钙结合蛋白4的¹H、¹⁵N和¹³C化学位移归属

¹H, ¹⁵N, and ¹³C chemical shift assignments of murine calcium-binding protein 4.

作者信息

Park Saebomi, Li Congmin, Ames James B

机构信息

Department of Chemistry, University of California, One Shields Avenue, Davis, CA, 95616, USA.

出版信息

Biomol NMR Assign. 2014 Oct;8(2):361-4. doi: 10.1007/s12104-013-9517-z. Epub 2013 Aug 8.

DOI:10.1007/s12104-013-9517-z
PMID:23925854
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3877709/
Abstract

Calcium-binding protein 4 (CaBP4) regulates voltage-gated Ca(2+) channels in retinal rod cells and specific mutations within CaBP4 are associated with congenital stationary night blindness type 2. We report complete NMR chemical shift assignments of the Ca(2+)-saturated form of CaBP4 with Ca(2+) bound at EF1, EF3 and EF4 (BMRB no. 18877).

摘要

钙结合蛋白4(CaBP4)调节视网膜视杆细胞中的电压门控钙通道,CaBP4内的特定突变与2型先天性静止性夜盲症相关。我们报告了CaBP4的Ca(2+)饱和形式的完整核磁共振化学位移归属,其中Ca(2+)结合在EF1、EF3和EF4位点(生物磁共振银行编号18877)。

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本文引用的文献

1
CaBP1, a neuronal Ca2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions.钙结合蛋白 1(CaBP1)是一种神经元钙传感器蛋白,通过夹闭亚基间相互作用抑制三磷酸肌醇受体。
Proc Natl Acad Sci U S A. 2013 May 21;110(21):8507-12. doi: 10.1073/pnas.1220847110. Epub 2013 May 6.
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Complex regulation of voltage-dependent activation and inactivation properties of retinal voltage-gated Cav1.4 L-type Ca2+ channels by Ca2+-binding protein 4 (CaBP4).钙结合蛋白 4(CaBP4)对视网膜电压门控 Cav1.4 L 型钙通道的电压依赖性激活和失活特性的复杂调节。
J Biol Chem. 2012 Oct 19;287(43):36312-21. doi: 10.1074/jbc.M112.392811. Epub 2012 Aug 30.
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Evolution and functional diversity of the Calcium Binding Proteins (CaBPs).钙结合蛋白(CaBPs)的进化和功能多样性。
Front Mol Neurosci. 2012 Feb 21;5:9. doi: 10.3389/fnmol.2012.00009. eCollection 2012 Jan 23.
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A null mutation in CABP4 causes Leber's congenital amaurosis-like phenotype.CABP4基因的无效突变会导致莱伯先天性黑蒙样表型。
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Structural insights into Ca2+-dependent regulation of inositol 1,4,5-trisphosphate receptors by CaBP1.CaBP1对肌醇1,4,5-三磷酸受体的Ca2+依赖性调节的结构见解
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Mutation of the calcium channel gene Cacna1f disrupts calcium signaling, synaptic transmission and cellular organization in mouse retina.钙通道基因Cacna1f的突变会破坏小鼠视网膜中的钙信号传导、突触传递和细胞组织。
Hum Mol Genet. 2005 Oct 15;14(20):3035-46. doi: 10.1093/hmg/ddi336. Epub 2005 Sep 9.
7
Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function.钙离子结合蛋白4(一种Cav1.4通道调节因子)在光感受器突触功能中的重要作用。
Nat Neurosci. 2004 Oct;7(10):1079-87. doi: 10.1038/nn1320. Epub 2004 Sep 26.
8
Calcium-binding protein 1 is an inhibitor of agonist-evoked, inositol 1,4,5-trisphosphate-mediated calcium signaling.钙结合蛋白1是激动剂诱发的、1,4,5-三磷酸肌醇介导的钙信号传导的抑制剂。
J Biol Chem. 2004 Jan 2;279(1):547-55. doi: 10.1074/jbc.M309617200. Epub 2003 Oct 21.
9
Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels.鉴定出一类钙传感器作为肌醇三磷酸受体Ca(2+)释放通道的蛋白质配体。
Proc Natl Acad Sci U S A. 2002 May 28;99(11):7711-6. doi: 10.1073/pnas.102006299.
10
Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin.一个与钙调蛋白相似的新型钙结合蛋白(CABP)亚家族的五个成员。
J Biol Chem. 2000 Jan 14;275(2):1247-60. doi: 10.1074/jbc.275.2.1247.