Leuthner Kimberly D, Doern Gary V
University Medical Center of Southern Nevada, Las Vegas, Nevada, USA.
J Clin Microbiol. 2013 Dec;51(12):3916-20. doi: 10.1128/JCM.01751-13. Epub 2013 Aug 7.
The development of antimicrobial agents represents one of the most significant achievements in medicine during the past century. However, the emergence of antimicrobial resistance combined with the downturn in the development of new antimicrobial agents in the pharmaceutical industry poses unanticipated challenges in the effective management of infection. The issue of how we can most effectively utilize these invaluable resources, antimicrobials, in the face of infections that are ever more difficult to treat arises. This issue serves as the fundamental basis for the concept of antimicrobial stewardship, the topic of this minireview.
抗菌药物的发展是过去一个世纪医学领域最重大的成就之一。然而,抗菌药物耐药性的出现,再加上制药行业新抗菌药物研发的低迷,给感染的有效管理带来了意想不到的挑战。面对越来越难以治疗的感染,如何最有效地利用这些宝贵的抗菌药物资源这一问题随之而来。这个问题是抗菌药物管理理念的根本基础,也是本综述的主题。