人巨细胞病毒亚病毒致密体刺激单核细胞来源的未成熟树突状细胞的成熟和激活。
Subviral dense bodies of human cytomegalovirus stimulate maturation and activation of monocyte-derived immature dendritic cells.
机构信息
Institute for Virology.
出版信息
J Virol. 2013 Oct;87(20):11287-91. doi: 10.1128/JVI.01429-13. Epub 2013 Aug 7.
Abstract
Dendritic cells play a central role in the immune control of human cytomegalovirus (HCMV) infection. This work aimed at investigating the impact of noninfectious, subviral dense bodies of HCMV on the maturation and activation of dendritic cells (DC). Treatment of immature DC with dense bodies led to the maturation of these cells and significantly increased their capacity for cytokine release and antigen presentation. Dense body-activated DC may thereby contribute to the development of antiviral immunity.
摘要
树突状细胞在人类巨细胞病毒（HCMV）感染的免疫控制中发挥核心作用。本研究旨在探讨 HCMV 的非感染性亚病毒致密体对树突状细胞（DC）成熟和激活的影响。用致密体处理未成熟的 DC 可导致这些细胞成熟，并显著增加其细胞因子释放和抗原呈递能力。因此，致密体激活的 DC 可能有助于抗病毒免疫的发展。
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