Herbst C P, Theron H D, van Aswegen A, Kleynhans P H, Otto A C, Minnaar P C
Department of Biophysics, University of the Orange Free State, Bloemfontein.
S Afr Med J. 1990 Sep 1;78(5):277-80.
Thallium-201 is at present the radiotracer of choice for the clinical evaluation of myocardial blood flow. Although different technetium-99m-isonitrile agents have been synthesised recently, only 99mTc-methoxyisobutyl-isonitrile (99mTc-MIBI) has proved to hold promise for clinical implementation. The myocardial distribution of 201Tl and 99mTc-MIBI was compared in a group of 20 patients, who underwent both 201Tl single photon emission computed tomography and 99mTc-MIBI study as well as coronary angiography. The sensitivity for predicting a lesion ranged from 25% to 88% in different areas of the heart and was comparable for the two radiopharmaceuticals. The specificity was greater than 80% for all regions except the inferior region where a specificity of 58% obtained by 99mTc-MIBI was better than the low specificity of 17% obtained with 201Tl (P less than 0.008).
铊 - 201是目前用于心肌血流临床评估的首选放射性示踪剂。尽管最近已经合成了不同的锝 - 99m异腈类药物，但只有锝 - 99m - 甲氧基异丁基异腈（99mTc - MIBI）已被证明有望用于临床实践。对一组20例患者进行了铊 - 201和99mTc - MIBI的心肌分布比较，这些患者同时接受了铊 - 201单光子发射计算机断层扫描、99mTc - MIBI研究以及冠状动脉造影。在心脏的不同区域，预测病变的敏感性范围为25%至88%，两种放射性药物的敏感性相当。除下壁区域外，所有区域的特异性均大于80%，在该区域，99mTc - MIBI获得的58%的特异性优于铊 - 201获得的17%的低特异性（P小于0.008）。
